VANIDERM AS GLUTATHIONE (GHS)

COMMON NAME:              GSH

CLINICAL NAME:              Glutathione

SYNONYM:                        Reduced L- glutathione

CHEMICAL NAME:           Gamma-L-glutamyl – L – cysteninylglycine or   
           L-7-glutanyl – cysteinylglycine

DEFINITION:                      L-Glutathione is biologically active sulfur amino acid  tripeptide
compound consisting of:

  • ·        L-Cysteine
  • ·        L-Glutamic acid
  • ·        Glycine



FOUND WHERE?

  • -        present in virtually in all mammalian tissue
  • -        mostly in liver where it detoxifies many harmful compounds to be excreted through the bile
  • -        red and white blood cells
  • -        lungs
  • -        intestinal tract


PRIMARY BIOLOGICAL FUNCTIONS:

  •        to act as a non-enzymatic reducing agent to help keep cysteine thiol side  chains in a reduce state on the surface of proteins
  •        involved in the synthesis & repair of DNA
  •        helps to recycle Vit. C and Vit. E
  •        blocks free radical damage
  •        enhances the anti-oxidant activity of Vit. C
  •        facilitates the transport of amino acids
  •        plays a critical role in the detoxification of harmful compounds
  •        is the base material for several other key antioxidant enzyme systems such as,glutathione-peroxidase, glutathione-reductase
and glutathione- transferase
  •        Body  (AID)       A  - ntioxidant         I   - mmune booster        D  - etoxifier

THEREFORE, declines in glutathione concentrations in intracellular fluids correlate directly with
indicators of aging.


DIETARY SOURCES:

Glutathione is derived from L-cysteine, L-glutamic acid and Glycine and is not consumed directly as a food constituent.

DEFICIENCY OF GLUTATHIONE CAUSES:

  •        coordination problems
  •        generalized cell damage
  •        mental disorders
  •        various nervous system disorders
  •        tremors and twitching
  •        red cells are prone to burst
  •        whit blood cells decline in function


DEFICIENCY OF INTRACELLULAR GLUTATHIONE has been associated with a variety of
conditions including

  •        AIDS (acquired immune deficiency syndrome)
  •        Alcohol induced liver diseases
  •        Some forms of cancer


PROVEN THERAPEUTIC USES:

  •        antioxidant action
  •        cancer
  •        cataracts
  •        liver diseases
  •        muscular degeneration


MECHANISM OF ACTION:

  •        support of antioxidant process
  •        modify the normal pigmentation pathway from eumelanin to pheomelanin


MAINTENANCE DOSE:

  •        As Antioxidant and as Antiaging dose: 10mg per kilogram bodyweight per day

  •        As Skin whitening: 20-40mg per kilo bodyweight per day  in 2-3 divided doses.

    Note: Best taken with preferably  30 minutes before meals. Should be taken together with
    Vitamin C  at least equal or twice the dose of the glutathione taken.


SIDE-EFFECTS:

Generally considered to be free of side-effects. No untoward side-effects nor interactions with
oral administration reported even in prolonged use.

It is SAFE. Classified as Food Supplement not a herbal. Made from genetically synthesize
molecules.

The only reported side- effect is SKIN WHITENING when taken in increased doses.


TOXICITY:

No toxicities have been reported or suspected as being associated with glutathione.


CONTRAINDICATIONS:

None known, except for use during some forms of chemotherapy and radiation where
antioxidants are contraindicated due to their inhibition of the free radical formation which is an
integral part of the therapeutic mechanism.


INTERACTIONS:

Nutrients affected by GLUTATHIONE  – CISPLATIN and HALOPERIDOL


WHO NEEDS GLUTATHIONE:

  • - 40 years old and above
  • - smokers
  • - alcoholic drinkers
  • - with low immune system
  • - with liver problems
  • - with thyroid problems
  • - has cataracts
  • - with pimples
  • - obese
  • - with low sperm counts
  • - with cancer
  • - those who wants to possess fairer and whiter skin


LOW GLUTATHIONE LEVELS ARE FOUND IN:

  • - Aging population
  • - Immunocompromised individuals
  • - With atherosclerosis
  • - Male infertility
  • - Pregnancy complications
  • - Hyperthyrodism
  • - Liver problems
  • - Cataracts
  • - Cancer
  • - Alzheimers, Parkinsons, M.S.
  • - Results of oxidative stress due to diseases, drugs pollution, radiation and smoking


IS IT SAFE IN THE LIVER?

    “ The higher GSH content, the greater the liver’s capacity to detoxify   harmful chemicals.”

    “ When exposed to chemicals which damages the liver, concentration of GSH decreases.”

    “ Reduction in GSH makes liver susceptible to damage.”

    - Dr. Murray’s  7/2003

    “ A small study in 8 patients of LIVER CANCER using oral GSH showed modest benefits when
    given daily amounts of 500mg GSH.”

                                                         - Dalhoff, Ranek, et. Al., 1992


IS IT SAFE  TO THOSE PERSONS WITH  THYROID  PROBLEMS?

    YES.

    “…both hypothyroidism and hyperthyroidism are associated with enhanced oxidative stress
    involving antioxidants.”
                                                              - Reschu, Helsel, et. Al.
                                                                 November, 2002

    “…has a direct relationship with free radical formation and inverse relationship with levels of
    erythrocute glutathione and glutathione peroxidase in human subjects.”

       Turkish Journal of Endocrinology & Metabolism, Feb.,2001



Is it Safe for Pregnant Women?

    Glutathione is generally safe since it is classified as processed food. There have been no
    specific data established yet.  But there are reports that clinicians use glutathione for better
    fetus development because it is an anti-oxidant.

    “Glutathione status plays an important role in the development of fetus because it controls cell
    differentation, proliferation and cell death.

    Placenta has a significant amount of G-S transferase which is capable of detoxification.
    Supplementation can decrease the incidence of birth defects and protect the fetus from
    damage.”

                                              The Glutathione Report, Priya Shah, April 2004


GLUTATHIONE AND HEART/ NEUROLOGIC DISEASES/ DIABETIC MELLITUS

    “CATALASE AND GSH Peroxidase were shown to potently decrease neurotoxity”

                                               Journal of Neurochemistry,  Vol. 87, Nov. 6, 2003, 1527-34

    “Low levels of Glutathione Peroxidase activity in erythrocytes is associated with an increased
    risk of Cardiovascular events in patients with coronary diseases.”

       New England Journal of Medicine, 2003

    DM & HYPERTENSIVE PATIENTS
    - associated with INCREASED FREE RADICAL DEPENDENT OXIDATIVE TISSUE DAMAGE

                                                             Barbagallo, et al., 1999


WHAT IS THE DOSAGE?        


    Dosage computation as ANTIOXIDANT/ ANTI-AGING:

    10 mg/kg/day

    Ex.  50kg male

    50kg body weight  x 10mg = 500 mg/day



    Dosage computation for SKIN WHITENING (double increased dose)  

    20-40 mg/kg/day

    Ex.  50 kg female

    50kg body wt x 30mg (median of 20 & 40) = 1500mg/ day in 3 divided doses

    Duration of Intake for skin whitening:       

    Medium brown skin:                1-3 months
    Dark brown skin:                      3-6 months
    Very brown skin:                       6-12 months
    Black skin:                                 2 years

    Upon reaching desired skin color, maintenance dose of once a day.

    Note:  Grapeseed Extrtact 1,000mg should be taken together with Vaniderm to enhance and speedup whitenings processes.
    Grapeseed extracts is 20x more powerful than Vit C and 50x more potent that Vit E.




What the Experts Say about Glutathione:


  •       “…that everyone should take antioxidant supplements and recommends about 4,000mg of Vitamin C per day as a part of
                                            that regimen”

        Dr. Anthony Verlangieri, Director of the Atherosclerosis
         Reseach Laboratory and Professor  of Pharmacology
         Toxicology ot the Univ. of Mississippi states


  •        GSH is one of the 14 “Superfoods” listed in SuperFoods Rx : Fourteen Foods That Will
         Change Your Life, co-authored by Dr. Steven Pratt, an authority on food and ageing.

  •        “Without GSH, other important antioxidants such as vitamins C and E cannot do their job
                      adequately to protect your body against disease”

    Allan Somersall, Ph.D., M.D., and Gustavo Bounous, M.D.
    FRCS(c) in Breakthrough in Cell Defense.

  •        “Blood GSH levels rose nearly 50% in healthy individuals taking 500mg of Vit. C because it
                      raises GSH by helping the body manufacture it and at the same time prevent GSH from being
                       oxidized.”
    – Dr. Murray’s  7/30/2003



ALPHA LIPOIC ACID  

Recommended dose: 50mg- 500/day

  • ·        The only antioxidant that can boost the level of GSH- Life Extension Foundation, Dec. 1999
  • ·         Alpha Lipoic Acid also helps increase GSH levels. – Dr. Murray’s  7/30/2003
  • ·        Antioxidant that prevents free radical damage, protects our liver, slows aging.
  • ·        Not only protect nerves but regenerates it.
  • ·        Has the ability to serve as a continuous supplier of cysteine.


DEFINITION OF TERMS:

    1. ANTIOXIDANT- compound that halts oxidative stress by donating its  electrons to neutralize
    free radicals before they can cause damage.

    2. OXIDATIVE STRESS- a damaging condition that occurs when there are too  many free
    radicals and not enough antioxidants to neutralize them.

    3. FREE RADICAL- a molecule or molecule fragment with an unpaired electron produced by the
    body and pollutants that causes damage to the body.
YUMI